US Special Forces killed ISIS leader Abu Ibrahim al-Hashimi al-Qurayshi in a counterterrorism mission in northwest Syria Wednesday evening, President Joe Biden announced Thursday morning.

It was the the biggest US raid in the country since the 2019 operation that killed ISIS leader Abu Bakr al-Baghdadi.

Sources on the ground reported multiple fatalities. At least 13 people were killed in clashes that took place during and after the raid — including six children and four women — according to the Syrian civil defense group, the White Helmets.

There were no US casualties, according to the Pentagon. Multiple administration officials told CNN that a bomb exploded by the target of the operation resulted in the civilian casualties, citing early assessments of the operation.

“Last night at my direction, US military forces in northwest Syria successfully undertook a counterterrorism operation to protect the American people and our Allies, and make the world a safer place,” Biden said in a statement. “Thanks to the skill and bravery of our Armed Forces, we have taken off the battlefield Abu Ibrahim al-Hashimi al-Qurayshi — the leader of ISIS. All Americans have returned safely from the operation.”

Pentagon press secretary John Kirby said in a statement late Wednesday night that the mission was conducted by US Central Command, which controls military operations and activities in the Middle East.

The Pentagon will conduct a more thorough after-action review of the raid. But one senior administration official said that “at the beginning of the operation, the terrorist target exploded a bomb that killed him and members of his own family, including women and children.”

“While we are still assessing the results of this operation, this appears to be the same cowardly terrorist tactic we saw in the 2019 operation that eliminated al-Baghdadi,” the official said.

US forces at the site of the raid called out to the ISIS leader to allow for civilians to be let out of building and several children did leave the premises, according to two US officials.

Witnesses say building ‘partially destroyed’

ISIS named al-Qurashi as its new leader in November 2019 at the same time that the terror group confirmed al-Baghdadi had been killed.

Witnesses and rescue workers told CNN that shelling and explosions preceded an airdrop of US forces shortly after midnight and targeted a house in the Syrian-Turkish border area of Atmeh, in the rebel enclave of Idlib.

In addition to the 13 killed, two people were also injured and a building was “partially destroyed” following the raid, according to the White Helmets.

The US has repeatedly targeted al Qaeda and its affiliates in northwest Syria, with the Pentagon acknowledging at least one strike in recent months may have resulted in civilian casualties. But Wednesday’s operation was the largest in scale since a two-hour raid killed ISIS leader Baghdadi in northwest Syria in October 2019.

Last September, the military targeted a senior al Qaeda leader near Idlib, Syria, according to a statement from Central Command. One month later, the military carried out a drone strike against Abdul Hamid al-Matar, a senior al Qaeda leader, Central Command said.

And then in December, the military targeted Musab Kinan, a senior leader of al Qaeda affiliate Hurras al-Din, near Idlib. Central Command opened an investigation into the possibility of civilian casualties from the strike, but the Pentagon was unable to provide updates at the time.

Meanwhile, various parts of Syria and Iraq have seen an ISIS resurgence. Last month, over 100 ISIS fighters attacked a prison in Syria’s northeast in an attempt to free jailed members of the extremist group. At least 200 prison inmates and 30 security forces died in the clashes that followed the thwarted jail break.